Searchable abstracts of presentations at key conferences in endocrinology

ea0083pno5 | Pituitary and Neuroendocrinology | EYES2022

Postoperative basal cortisol level as an indicator of pituitary surgery success in Cushing’s disease treatment: a single centre retrospective study

I. D. Vodanovic , A Balasko , I. Kraljevic , A Barac Nekic , T. Dusek , D. Kastelan

Background: Pituitary surgery is the primary therapy for Cushing’s disease (CD). Basal cortisol level (BCL) is measured postoperatively to evaluate the immediate efficacy of surgical treatment, but no definitive cut-off value has yet been determined as reliable. Our pituitary-dedicated centre uses an arbitrary BCL less than 50 nmol/l as expected early remission marker, identifying all patients with higher BCL as a risk group for early surgical failure.<p class="abstex...

ea0049ep81 | Adrenal cortex (to include Cushing's) | ECE2017

Long term follow up of patients with adrenal incidentaloma and ‘autonomous cortisol secretion’

Kraljevic Ivana , Solak Mirsala , Dusek Tina , Polovina Tanja Skoric , Balasko Annemarie , Kastelan Darko

The aim of this study was to compare the long-term co-morbidities and biochemical data between patients with adrenal incidentaloma and ‘autonomous cortisol secretion’ who were treated surgically and conservatively.Methods: The research of the database of the patients with adrenal incidentaloma diagnosed between 2007 and 2014 was performed. Among them, 43 patients with ‘autonomous cortisol secretion’ were identified and invited for a f...

ea0056p884 | Pituitary - Clinical | ECE2018

Clinical and treatment outcomes in patients with craniopharyngiomas – single center experience

Polovina Tanja Skoric , Solak Mirsala , Kraljevic Ivana , Dusek Tina , Spanovic Nemanja , Balasko Anne-Marie , Kastelan Darko

Craniopharyngiomas are rare and histologically benign tumors that are associated with an unfavourable prognosis and controversial optimal treatment. The aim of this retrospective study was to review clinical presentation, natural history and therapeutic outcomes of patients with craniopharyngiomas treated in a single center between 1995 and 2017. In that period, 38 patients (16 children and 22 adults) were diagnosed with craniopharyngioma. Median age at the time of diagnosis i...

ea0081rc7.1 | Rapid Communications 7: Pituitary and Neuroendocrinology 2 | ECE2022

Does the postoperative dose of hydrocortisone influence the health-related quality of life in patients with cured Cushing syndrome?

Kraljevic Ivana , Barac Anja , Solak Mirsala , Skoric Polovina Tanja , Balasko Annemarie , Zibar Tomsic Karin , Dusek Tina , Kastelan Darko

Objective: Patients with Cushing syndrome (CS) have impaired health-related quality of life (HRQoL) before and after surgery. The data on the optimal hydrocortisone dose after surgical cure of CS is scarce. Therefore, we investigated the influence of hydrocortisone dose on HRQoL after surgical treatment of CS. We hypothesized that patients who receive higher hydrocortisone doses after surgery would have better HRQoL and fewer cortisol withdrawal symptoms.<p class="abstext"...

ea0063p1092 | Pituitary and Neuroendocrinology 3 | ECE2019

Factors predicting dopamine agonist treatment withdrawal in prolactinoma patients

Solak Mirsala , Haxhiu Arta , Haxhiu Arita , Kraljevic Ivana , Dusek Tina , Leskovar Dunja , Polovina Tanja Skoric , Balasko Annemarie , Kastelan Darko

Aim: Dopamine agonist (DA) therapy is recommended as first-line treatment for prolactinomas, albeit with long treatment duration and high recurrence rate after treatment withdrawal. The aim of this retrospective study was to evaluate predictors for successful DA withdrawal.Methods: The study included 59 prolactinoma patients (39 female, 20 male; age 34 (18–82) years) that were treated with DA (35.6% on cabergoline); the duration of treatment was 71 ...

ea0049ep71 | Adrenal cortex (to include Cushing's) | ECE2017

Neutrophil-lymphocyte and platelet-lymphocyte ratios as biomarkers in distinguishing adrenocortical adenomas and carcinomas

Solak Mirsala , Kraljevic Ivana , Kastelan Marko , Kakarigi Luka , Dusek Tina , Polovina Tanja Skoric , Balasko Annemarie , Knezevic Nikola , Kastelan Darko

The role of systemic inflammation in promoting tumor progression has been a topic of increasing interest. Neutrophil-lymphocyte ratio (NLR) >5 and platelet-lymphocyte ratio (PLR) >190 used as indicators of inflammation have been reported to have prognostic value in numerous solid tumors. The aim of this retrospective study was to investigate NLR and PLR as biomarkers in distinguishing between adrenocortical adenomas and adrenocortical carcinomas (ACC). Nineteen patient...

ea0056p855 | Pituitary - Clinical | ECE2018

Hypopituitarism in primary empty sella

Tomsic Karin Zibar , Deskin Marin , Kraljevic Ivana , Dusek Tina , Solak Mirsala , Polovina Tanja Skoric , Balasko Annemarie , Kastelan Darko

Empty sella is characterized by the radiological appearance of an enlarged or deformed sella turcica which is completely or partially filled with cerebrospinal fluid resulting in a displacement of the normal pituitary gland. Primary empty sella (PES) refers to the empty sella appearance of unknown etiology, diagnosed after excluding a history of previous pituitary pathology. The prevalence of hypopituitarism in empty sella syndrome varies between 2 and 32% in different publish...

ea0099ep29 | Calcium and Bone | ECE2024

The usefulness of 18F-choline PET/CT in patients with negative findings on 99mTc-sestamibi SPECT/CT in Locating Hyperfunctioning Parathyroid Glands in Primary Hyperparathyroidism

Mandic Ante , Kraljevic Ivana , Skoric Polovina Tanja , Zibar Tomsic Karin , Dusek Tina , Balasko Annemarie , Solak Mirsala , Kastelan Darko

Objective: This study aimed to investigate the diagnostic performance of 18F-choline PET/CT in patients with negative or inconclusive results of 99mTc-sestamibi SPECT/CT in locating hyperfunctioning parathyroid tissue in primary hyperparathyroidism patients.Methods: We conducted a retrospective study involving patients who were operated on due to primary hyperparathyroidism from April 2019 to March 2022. The analysis focused on pati...

ea0099ep140 | Pituitary and Neuroendocrinology | ECE2024

Long-term outcomes of non-functioning pituitary macroadenomas following surgery

Solak Mirsala , Kraljevic Ivana , Brekalo Roman , Skoric Polovina Tanja , Balasko Annemarie , Zibar Tomsic Karin , Popovac Hrvoje , Dusek Tina , Kastelan Darko

Background: Systematic or randomised studies on the natural course of non-functioning pituitary macroadenomas after surgery (NFPA) are lacking.Objectives: This study aimed to evaluate the long-term outcomes of residual NFPA following pituitary surgery.Methods: In this retrospective study, we included 130 patients with NPFA who underwent pituitary surgery between 2005 and 2018 at University Hospital Centre Zagreb. The median age of ...

ea0081p694 | Pituitary and Neuroendocrinology | ECE2022

Radiological classification of craniopharyngioma based on its origin

Skoric Polovina Tanja , Ozretic David , Solak Mirsala , Kraljevic Ivana , Dusek Tina , Balasko Annemarie , Zibar Tomšić Karin , Kastelan Darko

Recognizing the site of origin of craniopharyngioma (CP) along the hypothalamus-pituitary axis according to pre-operative MR is helpful to understand its growth pattern in relation to hypothalamus, which is critical in the prediction of hypothalamic injury and planning of treatment. We retrospectively classified 29 CP according to MR pre-operative image study using modified classification of Tang et al. (Nature, 8:10215, 2018). According to its relation to pituitary s...